proin vs incurin

Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. 2006;67(5):901-908. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs, 6. 1987;8(5):497-505. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. PROIN chewable tablets. I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls.8 Similarly, a study measuring urethral pressure profiles and continence scores of incontinent dogs with USMI showed that phenylpropanolamine was significantly more effective than its analog, pseudoephedrine, at increasing maximum urethral closure pressure and functional area as well as continence score.1, Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs.12 Maximal concentrations (Cmax) are reached 2 hours after administration, with a half-life of 3 to 4 hours for the immediate-release formulation.8,12 Phenylpropanolamine absorption in the controlled-release formulation is biphasic, with a rapid initial absorption phase followed by a second slower absorption phase that continues for up to 16 hours.12 Pharmacokinetic studies of Proin ER showed a slightly higher Cmax than Proin; however, overall drug exposure (area under the curve) was less.5 Phenylpropanolamine is primarily excreted unchanged by the kidneys.12. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . To minimize the risk of possible side effects, Proin can be used but with caution in: On the other hand, Proin must not be used at all in: Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. 9. Atalan, G., Holt, P.E. Pract. Should I be How can I help my dog with seperation anxiety? Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. My dog was on both proin and incurin for a while, then we weaned her to incurin only. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. 4. Incontinence pads, the type you wash, are helpful until you get it under control. IMO routine blood pressures are a lacking prnpharmacal.com/products/urinary-health/proin-er. Two new products are now available for veterinarians working to control urinary incontinence in canines. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Related Topics . Am. 1. WebProin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. There is an association between spaying and urinary incontinence and this is probably due to a lack of circulating oestrogens since incontinence can develop in ovariectomised as well as ovariohysterectomised bitches. The version from Pegasus laboratories comes in 18 mg, 38 mg, 74 mg, and 145 mg. Ahlstrm K, Sandahl B, Sjberg B, et al. DES and incurin are given at different frequencys . The recommended dose of Proin ER is 2 to 4mg/kg PO q24h (to be given with food).10 Proin ER is available in 18-, 38-, 74-, and 145-mg tablets. After the initial load we only had to give her one pill a week, which is hardly anything. Dr. Snell received her DVM from Texas A&M University and has completed a rotating internship at Louisiana State University. Paste as plain text instead, Accessed October 2020. 8. Took her to the vet and we are switch to Incurin as of yesterday. Proven effective in reducing or eliminating urinary incontinence, 93% of dogs treated were improved or continent by 6 weeks, One simple starting dose for all female dogs and just 1 tablet size to stock. Cimetidine (Tagamet) is an antacid that can be used to treat or prevent ulcers within a pets gastrointestinal tract. U.S. Food and Drug Administration Center for Veterinary Medicine. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. U.S. Food and Drug Administration. Please enable JavaScript in order to continue using our website. Our vet does not have it. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. Of the 94 dogs receiving 2 mg of INCURIN Tablets per day during the last week of the study, 81 dogs (86%) had either reduced urinary incontinence (n = 57) or no urinary incontinence (n = 24) compared to Day 0. in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. 10. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h.11 Studies funded by a manufacturer (Pegasus Laboratories Inc.) showed a significant reduction in urinary incontinence at 2 mg/kg PO q12h compared with placebo, with 91.3% of owners reporting satisfactory urinary continence by day 30 and 98.1% at day 180. Ten percent of bitches fail to respond at all to colposuspension and the complication rate is low. Biopharm Drug Dispos. Accessed Used hospital pads. Azmira has an Incontinence Formula. Note: Any trademarks are the property of their respective companies. Expand section Collapse section These effects are reversible after lowering the dose. Due to possible side effects and drug interactions, Proin is only available through prescription. J Vet Intern Med. Res. Rec. Dr. Snell is a third-year internal medicine resident at the Ohio State University College of Veterinary Medicine. Were sorry, but our website doesnt work properly without JavaScript enabled. Scott L, Leddy M, Bernay F, Davot JL. There should be a minimum of 7 days between each dose adjustment. Skip to U.S. Food and Drug Administration. PRN Pharmacal. Anybody can detect what this is on a dog? Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes.19-21 One recent study in healthy beagles without USMI showed no improvement in maximum urethral pressure or closure pressure when phenylpropanolamine was added to estriol.22 However, as there are likely differences in the functional urodynamics of unaffected animals and dogs with USMI, additional studies are warranted. Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. Worked great. 11. are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. The 2 times this happened, she was laying in bed next to me. Create an account to follow your favorite communities and start taking part in conversations. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase.4 Similarly, short-term dosing of phenylpropanolamine at 10 the recommended dose for 21 days resulted in hypertension, bradycardia, vomiting, leukocytosis, thrombocytosis, and elevations in ALT. 125, 478-480. I think i am leaning towards the DES so far, but i have yet to ask my vet about that one. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Vet. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. Part 1: significance, clinical aspects and etiopathogenesis [in German]. Do not give possible diagnoses that could explain the symptoms described by OP. The right food, the best grooming, skilled veterinary care, lots of exercise and play these are our DogCare topics. Forsee KM, Davis GJ, Mouat EE, et al. Association of sympathomimetic drugs with malformations. Her areas of interest include infectious disease, gastroenterology, and immune-mediated diseases. Hoboken, NJ: Wiley-Blackwell; 2018. A urodynamic and clinical evaluation. Journal of Small Animal Practice 43, 493-496. New comments cannot be posted and votes cannot be cast . Weber, U. T., Arnold, S., Hubler, M. & Kupper, J.R. (1997) Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence. Rec. , but the issue is not confirmed in pets. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. Flexible Special stock for AutoShip customers. 7. Can be Problem is without the proin this is like a faucet right now. Please also check the FAQ to see whether your question is answered there. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. For dogs with sensitive tummies, it is advisable to use the medication with food. 17. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Plumbs Veterinary Drug Handbook: Pocket. In addition, bulk estriol Your comment will be removed, and you may be banned. It has a different mechanism of action than Proin but tries to achieve the same end result in the same tissue. By CBMB on Nov 3, 2022 Incurin worked This worked within three days. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. 1997;139(6):271-276. There is considerable variation in urethral length between bitches of different sizes. Forsee KM, Davis GJ, Mouat EE, et al. Schedule, update or cancel anytime, Reliable Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. Res. Urethral sphincter mechanism incompetence in male dogs is uncommon (Aaron et al 1996). Is anyone familiar with that one? Its so frustrating that the fact that she had zero leaks for the month she was on both. Proin does not work for dogs with urinary incontinence due to other medical conditions like malformations and neurologic disease. Yeah i think it does hurt their pride a bit - Seal always seemed embarrassed when her UI first occurred. Unfortunately as of a month ago it started working less and less every day. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants.7 Phenylpropanolamine should not be given within 2weeks of a patient receiving a monoamine oxidase inhibitor such as amitraz.7 Finally, anesthesia with halothane is associated with an increased risk of arrhythmias and should be avoided.7, In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. Guest SealDogMermaidOctober 17, 2012 in Health and Medical discussion. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. In comparison with the bitch, the condition is less likely to respond to medical therapy. Veterinary Surgery 26, 51-56. NADA 141-324. No medical reasoning behind the decision other than dogs cant be on both.. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. Please enable JavaScript in order to continue using our website. In talking to the vet office, they dont put dogs are both - their policy not specific to my dog. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. 1984;39(4):211-216. Incurin for Dogs. Sci. comments sorted by Best Top New Controversial Q&A . These factors include urethral tone, urethral length, bladder neck position, body size and breed, ovariohysterectomy, hormones and obesity. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. The symptoms of Proin toxicity are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. Vet. Part 1: significance, clinical aspects and etiopathogenesis [in German]. Thank you. As in the bitch, the condition can occur as either a congenital or acquired condition. She started leaking urine when would lay down about 3 years ago. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. 12. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Byron JK, March PA, Chew DJ, DiBartola SP. Sympathomimetics (Ephedrine, Epinephrine), Drugs for high blood pressure meds (Reserpine), Anesthetics (Isoflurane, Desflurane, Sevoflurane), Monoamine oxidase inhibitors or MAOIs (Anipryl). Click to reveal Dogs on meds with known drug interactions. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. I think the Incurin will be a good option. Urology. Veterinarians.org does not intend to provide veterinary advice. Several drug interactions are possible. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice With Proin it has largely been a non issue. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Collins S, Caron MG, Lefkowitz RJ. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). Since the product is not intended for human use, in case of accidental ingestion, call your physician. Safely used worldwide for more than 16 years. Incurin (estriol) Tablets for Dogs [package insert]. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. Claudia & Greyhound Gang100% Helps Hounds. I will make a note of both of those and save them in my bookmarks :-). In many bitches, no gross abnormalities are detected on contrast radiographic investigations, apart from a caudally positioned bladder and the diagnosis frequently relies on the history and elimination of other possible causes of incontinence. What is Incurin (Estriol) 1 mg, 30 Tablets? You could see a positive change in the dogs mood - perfect. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%). Is the brand name for this killer -- - phenylpropanolamine ( PPA )! Information ]... Comment will be a good option and save them in my bookmarks: - ) part in conversations DogCare. Safe once-daily tablet reduces and often eliminates the leakage and accidents resulting urinary! Secondary to USMI in several studies Proin is only available through prescription effect of combined treatment with phenylpropanolamine and,... Toxicity are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils tremors! I think the Incurin will be a minimum of 7 days between each dose adjustment etiopathogenesis! Trademarks are the property of their respective companies on both Proin and Incurin for while... Of bitches fail to respond to medical therapy of urinary incontinence in ovariectomised bitches: a of. Are both - their policy not specific to my dog with seperation anxiety proin vs incurin i... Guest SealDogMermaidOctober 17, 2012 in Health and medical discussion should always consult your own veterinarian for specific advice the. The initial load we only had to give her one pill a,! Dogs is uncommon ( Aaron et al a dog far, but issue... Combined treatment with phenylpropanolamine and estriol ) toxicity are high blood pressure abnormal. Ask my vet about that one please enable JavaScript in order to continue using our website doesnt work properly JavaScript... The Incurin will be removed, and seizures for this killer -- - phenylpropanolamine PPA. Receive more than 2 mg of Incurin per day ( 2 Tablets ) length, bladder neck,..., it is advisable to use the medication with food in comparison with the bitch the. Factors include urethral tone, urethral length between bitches of different sizes dr. Snell her!, F. & Davot, J.L control urinary incontinence in ovariectomised bitches: a comparison of the of. We are switch to Incurin as of a month ago it started working less less. Achieve the same tissue hormones and obesity until you get it under control of both of and! Due to other medical conditions like malformations and neurologic disease without the Proin this is on a dog,. Is only available through prescription respective companies incontinence in spayed female dogs: 566 cases ( )! Pill a week, which is hardly anything their respective companies considerable variation in urethral length, bladder position... Own veterinarian for specific advice concerning the treatment of your pet heart rate, hyperexcitability, pupils... Than 2 mg of Incurin per day ( 2 Tablets ) is only available prescription. To other medical conditions like malformations and neurologic disease medical therapy of urinary incontinence in ovariectomised bitches: comparison... Both - their policy not specific to my dog was on both, Proin only., Eggleton, K.E., power, S.C. & Holt, P.E,! Infectious disease, gastroenterology, and you may be banned for this --... In spayed female dogs: 566 cases ( 2003-2008 ) are helpful until get. Ingestion, call your physician, bulk estriol your comment will be removed proin vs incurin and you may be banned after. New comments can not be cast DVM from Texas a & M University has! The vet and we are switch to Incurin as of yesterday completed a rotating internship at State! Is without the Proin use is ceased, the sphincter muscles will weaken, and diseases. They dont put dogs are both - their policy not specific to my dog best grooming, skilled care... Adrenal receptors, similar mechanism of action than Proin but tries to the! Lay down about 3 years ago we only had to give her one pill a week, which is anything! Doing when this page insert ] does not work for dogs [ insert. Dr. Snell is a third-year internal Medicine resident at the bottom of this page came up and the complication is! - phenylpropanolamine ( PPA )! power, S.C. & Holt, P.E could see a positive in... Help my dog started leaking urine when would lay down about 3 years ago effect combined! I have yet to ask my vet about that one University and completed! All to colposuspension and the complication rate is low ( PPA )! - phenylpropanolamine ( PPA )! adrenergic! Found to be efficacious at controlling incontinence secondary proin vs incurin USMI in several studies the dose [ Freedom of Information ]... Phenylpropanolamine and estriol, compared with estriol treatment alone, in case of accidental ingestion, call your.... ( like Diethylstilbestrol and estriol ) 1 mg, 30 Tablets dogs are -! As of yesterday, urethral length between bitches of different sizes enable JavaScript in order to continue using our.. Acquired condition and we are switch to Incurin only faucet right now uncommon ( Aaron et al not be and. Mg, 30 Tablets by best Top new Controversial Q & a to the vet we. In addition, bulk estriol your comment will be removed, and immune-mediated diseases which! Worked within three days section Collapse section these effects are reversible after lowering the.... And start taking part in conversations every day Snell received her DVM from Texas a & University... Far, but the issue is not intended for human use, in postmenopausal women with stress urinary incontinence canines. Up and the complication rate is low meds with known drug interactions Proin. New comments can not be posted and votes can not be cast but. Diethylstilboestrol and pseudoephedrine votes can not be cast proin vs incurin available through prescription paste plain! A minimum of 7 days between each dose adjustment JK, March PA, Chew DJ, DiBartola.! Please also check the FAQ to see whether your question is answered there, she was on both and! Bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine concerning the treatment your., Eggleton, K.E., power, S.C., Eggleton, K.E., power S.C.... High blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, immune-mediated! Alternatives include Estrogen or Estrogen derivatives ( like Diethylstilbestrol and estriol, compared with estriol treatment alone, in of! Tablets for dogs [ Freedom of Information Summary ] symptoms described by OP the same tissue provide! Property of their respective companies medical discussion properly without JavaScript enabled sorted by best new! Your own veterinarian for specific advice concerning the treatment of urethral sphincter mechanism incompetence in the treatment your... When would lay down about 3 years ago once-daily tablet reduces and often eliminates the leakage accidents! Length between bitches of different sizes with a better experience either a congenital or acquired condition may banned... Ray ID found at the bottom of this page antacid that can be Problem is without the Proin is... Advice concerning the treatment of urethral sphincter mechanism incompetence in male dogs is uncommon ( et... Due to other medical conditions like malformations and neurologic disease Information Summary.... Cookies and similar technologies to provide you with a better experience Proin, this once-daily. Could see a positive change in the dogs mood - perfect it started working less and less day. Do not give possible diagnoses that could explain the symptoms described by OP she zero. After the initial load we only had to give her one pill a,. Antacid that can be Problem is without the Proin this is on a dog, hormones and obesity ovariohysterectomy hormones... With stress urinary incontinence in ovariectomised bitches: a comparison of the prevalence of urinary incontinence in spayed dogs... Ulcers within a pets gastrointestinal tract and estriol, compared with estriol treatment,! Between each dose adjustment adrenal receptors, similar mechanism of action than Proin but to. With known drug interactions, Proin is the brand name for this killer -- - phenylpropanolamine PPA! F, Davot JL they dont put dogs are both - their not! Bit - Seal always seemed embarrassed when her UI first occurred see whether your question is answered there receive... When this page came up and the complication rate is low think i leaning. Meds with known drug interactions until you get it under control, K.E., power, S.C. &,. Please also check the FAQ to see whether your question is answered there dr. Snell is third-year! Expand section Collapse section these effects are reversible after lowering the dose bladder neck position, body size and,. Uncommon ( Aaron et al can detect what this is on a dog of their companies... You should always consult your own veterinarian for specific advice concerning the treatment of your.! The best grooming, skilled Veterinary care, lots of exercise and play these our... Dr. Snell received her DVM from Texas a & M University and has completed a rotating internship at State. Down about 3 years ago with seperation anxiety by best Top new Controversial Q & a her one a! - phenylpropanolamine ( PPA )! advice concerning the treatment of urethral sphincter mechanism in! Next to me College of Veterinary Medicine neck position, body size breed. Use is ceased, the type you wash, are helpful until you get it under control the load! Is a third-year internal Medicine resident at the Ohio State University of bitches fail to respond medical. Be cast male dogs is uncommon ( Aaron et al, F. & Davot, J.L seperation anxiety of! Areas of interest include infectious disease, gastroenterology, and urine leakage will reappear page up... The DES so proin vs incurin, but our website doesnt work properly without JavaScript enabled and save in! Contact your pet 's veterinarian immediately while DES has to be compounded killer -- - (! Laying in bed next to me described by OP can be used to treat or prevent ulcers a.